OIE Reference Laboratory Reports Activities

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1 OIE Reference Laboratory Reports Activities Activities in 2013 This report has been submitted : :50:49 Name of disease (or topic) for which you are a designated OIE Reference Laboratory: Highly and low pathogenic avian influenza Address of laboratory: OIE Reference Laboratory for Avian Influenza disease Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), Viale dell Università Legnaro (PD) - Italy Tel.: Fax: address: icapua@izsvenezie.it website: Name (including Title) of Head of Laboratory (Responsible Official): Giovanni Cattoli Director of the Research and Innovation Department Istituto Zooprofilattico Sperimentale delle Venezie Viale dell Università Legnaro- Padova, Italy Name (including Title and Position) of OIE Reference Expert: Ilaria Capua Director Division of Comparative Biomedical Sciences OIE Reference laboratory for Newcastle Disease and Avian Influenza FAO Reference Centre for Animal Influenza and Newcastle Disease Istituto Zooprofilattico Sperimentale delle Venezie Which of the following defines your laboratory? Check all that apply: Governmental OIE Reference Laboratory Reports Activities,

2 ToR: To use, promote and disseminate diagnostic methods validated according to OIE Standards 1. Did your laboratory perform diagnostic s for the specified disease/topic for purposes such as disease diagnosis, screening of animals for export, surveillance, etc.? (Not for quality control, proficiency ing or staff training) Diagnostic Test Indicated in OIE Manual (/No) Total number of performed last year Indirect diagnostic s Nationally Internationally Haemoagglutination inhibition (HI) C-ELISA (AI-type A) AGID Direct diagnostic s Nationally Internationally Virus isolation Real-time RT-PCR RT-PCR Sequencing of AIV genes ToR: To develop reference material in accordance with OIE requirements, and implement and promote the application of OIE Standards. To store and distribute to national laboratories biological reference products and any other reagents used in the diagnosis and control of the designated pathogens or disease. 2. Did your laboratory produce or supply imported standard reference reagents officially recognised by the OIE? No 3. Did your laboratory supply standard reference reagents (non OIE-approved) and/or other diagnostic reagents to OIE Member Countries? 2 OIE Reference Laboratory Reports Activities, 2013

3 Type of reagent available Related diagnostic Produced/ provide Amount supplied nationally (ml, mg) Amount supplied internationally (ml, mg) No. of recipient OIE Member Countries Region of recipients Control positive antigens HI serological (ml) 1428 (ml) 0 1 Asia and Pacific Middle East Control positive antigens HI serological (ml) 628 (ml) 17 Asia and Pacific Middle East Control positive sera HI/AGID serological 726 (ml) 314 (ml) Asia and Pacific Middle East Control positive sera HI/AGID serological 726 (ml) 542 (ml) 17 Asia and Pacific Middle East Control negative serum HI serological 160 (ml) 77 (ml) Asia and Pacific Middle East Control negative serum HI serological 160 (ml) 27 (ml) 12 Asia and Pacific Middle East 4. Did your laboratory produce vaccines? No 5. Did your laboratory supply vaccines to OIE Member Countries? No OIE Reference Laboratory Reports Activities,

4 ToR: To develop, standardise and validate, according to OIE Standards, new procedures for diagnosis and control of the designated pathogens or diseases 6. Did your laboratory develop new diagnostic methods validated according to OIE Standards for the designated pathogen or disease? 7. Did your laboratory develop new vaccines according to OIE Standards for the designated pathogen or disease? No Name of the new or diagnostic method or vaccine developed Description and References (Publication, website, etc.) H5 RT-PCR Laboratory validation of the protocol described in: Slomka MJ, Coward VJ, Banks J, Löndt BZ, Brown IH, Voermans J, Koch G, Handberg KJ, Jørgensen PH, Cherbonnel Pansart M, Jestin V, Cattoli G, Capua I, Ejdersund A, Thorén P, Czifra G. Identification of sensitive and specific avian influenza polymerase chain reaction methods through blind ring trials organized in the an Union. Avian Dis Mar;51(1 Suppl): H7 RT-PCR Laboratory validation of the protocol described in: Slomka MJ, Coward VJ, Banks J, Löndt BZ, Brown IH, Voermans J, Koch G, Handberg KJ, Jørgensen PH, Cherbonnel Pansart M, Jestin V, Cattoli G, Capua I, Ejdersund A, Thorén P, Czifra G. Identification of sensitive and specific avian influenza polymerase chain reaction methods through blind ring trials organized in the an Union. Avian Dis Mar;51(1 Suppl): ToR: To provide diagnostic ing facilities, and, where appropriate, scientific and technical advice on disease control measures to OIE Member Countries 8. Did your laboratory carry out diagnostic ing for other OIE Member Countries? 4 OIE Reference Laboratory Reports Activities, 2013

5 Name of OIE Member Country seeking assistance Date (month) No. samples received for provision of diagnostic support No. samples received for provision of confirmatory diagnoses MOROCCO April 2 0 LIBYA April 0 18 JORDAN May 36 0 EGYPT May JORDAN June 6 0 SAUDI ARABIA June 34 0 SAUDI ARABIA July 42 0 EGYPT September 49 0 BANGLADESH September 6 0 COSTA RICA October 15 0 IRAQ November 34 0 LIBYA December 5 9. Did your laboratory provide expert advice in technical consultancies on the request of an OIE Member Country? Name of the OIE Member Country receiving a technical consultancy Purpose How the advice was provided IRAN OIE Twinning In loco and remote assistance EGYPT HPAI and H9N2 vaccination and control In loco and remote assistance AZERBAIJAN Laboratory assessment with special focus on HPAI and ND diagnostic capacity In loco and remote assistance SAUDI ARABIA H9N2 vaccination Remote ToR: To carry out and/or coordinate scientific and technical studies in collaboration with other laboratories, centres or organisations 10. Did your laboratory participate in international scientific studies in collaboration with OIE Member Countries other than the own? OIE Reference Laboratory Reports Activities,

6 Title of the study Duration Purpose of the study Partners (Institutions) FP7-FLUPIG 4 years Pathogenesis and transmission of influenza in pigs Universiteit Gent, Istituto Zooprofilattico Sperimentale delle Venezie, Imperial College of Science, Technology and Medicine, The Secretary of State for Environment, Food and Rural Affairs, Philipps Universitaet Marburg, Erasmus Universitair Medisch Centrum, Panstwowy Instytut Weterynaryjny Panstwowy Instytut Badawczy, HKU Pasteur Research Centre Limited, Kansas State University, Friedrich Loeffler Institut Bundesforschungsinstitut Fuer Tiergesundheit FP7-ESNIP III 3 years an surveillance network for influenza in pigs Veterinary Laboratories Agency, Ghent University, AFSSA- LERAPP, Istituto Zooprofilattico Sperimentale della Lombardia e dell Emillia Romagna, Technical University of Denmark, National Veterinary Institute, Pulawy, Laboratorio Central Veterinario-Sanidad Animal, IDT Biologika Gmbh, Finnish Food Safety Authority, Kimron Veterinary Institute, Central Agricultural Office Veterinary Diagnostic Directorate, Central Veterinary Institute of Wageningen UR, University of Thessaly, Sanger Institute, University of Cambridge, University of Oxford, Freidrich-Loeffler-Institut, Istituto Zooprofilattico Sperimentale delle Venezie, St. Judes Research Hospital, United States Department of Agriculture, Harbin Veterinary Institute, Merial S.A.S MSS, Laboraotorios Hipra, S.A, Animal Health Trust, Agri-Food & Biosciences Institute FP7-PREDEMICS 5 years Preparedness, Prediction and Prevention of Emerging Zoonotic Viruses with Pandemic Potential using Multidisciplinary Approaches Institut Pasteur, Istituto Zooprofilattico Sperimentale delle Venezie,Katholieke Universiteit Leuven, Université de la Méditerrannée Aix-Marseille 2, Eidgenössisches Volkswirtschaftsdepartment, Imperial College of Science, Technology and Medicine, Agence Nationale de Sécurité Sanitaire, Max Planck Gesellschaft zur Foerderung der Wissenschaften E.V., Fundación Caubet-Cimera, Swedish Institute for Infectious Disease Control, Philipps Universität Marburg, Istituto Nazionale Malattie Infettive Lazzaro Spallanzani, University of Edinburgh, Institute for Scientific Interchange Foundation, Health Sciences e Training Foundation EFSA-FLURISK 2 years Development of a risk assessment methodological framework for potentially pandemic influenza strains Istituto Zooprofilattico Sperimentale delle Venezie (coordinator), Veterinary Laboratories Agency, National Institute for Public Health and the Environment, Pasteur Institute, Ghent University EMIDA ERA-Net Epi-Seq 3 years Molecular epidemiology of epizootic diseases using next generation sequencing technology CODA-CERVA, Friedrich-Loeffler-Institut, Swedish University of Agricultural Sciences, Institute for Animal Health, Istituto Zooprofilattico Sperimentale delle Venezie, University of Glasgow OIE Twinning 2 years Implementation of capacity building of the CVL for the early detection and diagnosis of AI and ND and other major viral diseases of poultry IZSVe, CVL-IVO ANIHWA - NADIV 3 years Cooperation and coordination of National Research Programmes on Animal Health and Welfare of farm animals, including fish and bees IZSVe, Kimron Vet. Insititute Israel 6 OIE Reference Laboratory Reports Activities, 2013

7 ToR: To collect, process, analyse, publish and disseminate epizootiological data relevant to the designated pathogens or diseases 11. Did your Laboratory collect epizootiological data relevant to international disease control? 12. Did your laboratory disseminate epizootiological data that had been processed and analysed? 13. What method of dissemination of information is most often used by your laboratory? (Indicate in the appropriate box the number by category) a) Articles published in peer-reviewed journals: Aiello, R., Beato, M. S., Mancin, M., Rigoni, M., Romero Tejeda, A., Maniero, S., et al. (2013). Differences in the detection of highly pathogenic avian influenza H5N1 virus in feather samples from 4-week-old and 24-week-old infected pekin ducks (anas platyrhynchos var. domestica). Veterinary Microbiology, 165(3-4), Authie, E., Berg, C., Bøtner, A., Browman, H., Capua, I., De Koeijer, A., Depner, K., Domingo, M., Edwards, S., Fourichon, C., Koenen, F., More, S., Raj, M., Shivonen, L., Spoolder, H., Stegeman, J., Thulke, H., Velarde, A., Vågsholm, I., Willeberg, P., and Zientara, S. (EFSA AHAW Panel - EFSA Panel on Animal Health and Welfare), Scientific Opinion on monitoring procedures at slaughterhouses for poultry. EFSA Journal 2013;11(12):3521, 65 pp. doi: /j.efsa Authie, E., Berg, C., Bøtner, A., Browman, H., Capua, I., De Koeijer, A., Depner, K., Domingo, M., Edwards, S., Fourichon, C., Koenen, F., More, S., Raj, M., Shivonen, L., Spoolder, H., Stegeman, J., Thulke, H., Velarde, A., Vågsholm, I., Willeberg, P., and Zientara, S. (EFSA AHAW Panel - EFSA Panel on Animal Health and Welfare), Scientific opinion on the possible risks posed by the influenza A (H3N2v) virus for animal health and its potential spread and implications for animal and human health. EFSA Journal 2013;11(10):3383, 64 pp. doi: /j.efsa Beato, M. S., Mancin, M., Yang, J., Buratin, A., Ruffa, M., Maniero, S., et al. (2013). Antigenic characterization of recent H5N1 highly pathogenic avian influenza viruses circulating in Egyptian poultry. Virology, 435(2), Beato, M. S., Realpe-Quintero, M., Bonfante, F., Mancin, M., Ormelli, S., Terregino, C., et al. (2013). Cross-clade protection against H5N1 HPAI strains recently isolated from commercial poultry in egypt with a single dose of a baculovirus based vaccine. Vaccine, 31(44), Bonfante, F., Patrono, L. V., Aiello, R., Beato, M. S., Terregino, C., & Capua, I. (2013). Susceptibility and intraspecies transmission of the H9N2 G1 prototype lineage virus in japanese quail and turkeys. Veterinary Microbiology, 165(1-2), Capua, I., & Alexander, D. J. (March 2013). Influenza aviaire et maladie de newcastle. Un manuel de terrain et de laboratoire, Springer. 8. Capua, I. (2013). Joining the dots on the emergence of pandemic influenza. Journal of Clinical Virology : The Official Publication of the Pan American Society for Clinical Virology, 58, Capua, I. (2013). Three open issues on avian influenza H5, H7, H9 against all odds. British Poultry Science, 54(1), Capua, I., & Cattoli, G. (2013). Prevention and control of highly pathogenic avian influenza with particular reference to H5N1. Virus Research, doi: /j.virusres [Epub ahead of print]. 11. Capua, I., Mercalli, A., Pizzuto, M. S., Romero-Tejeda, A., Kasloff, S., De Battisti, C., et al. (2013). Influenza A viruses grow in human pancreatic cells and cause pancreatitis and diabetes in an animal model. Journal of Virology, 87(1), OIE Reference Laboratory Reports Activities,

8 12. Capua, I., & Munoz, O. (2013). Emergence of influenza viruses with zoonotic potential: Open issues which need to be addressed. A review. Veterinary Microbiology, 165(1-2), De Battisti, C., Salomoni, A., Ormelli, S., Monne, I., Capua, I., & Cattoli, G. (2013). Rapid pathotyping of newcastle disease virus by pyrosequencing. Journal of Virological Methods, 188(1-2), Fentie, T., Heidari, A., Aiello, R., Kassa, T., Capua, I., Cattoli, G., et al. (2013). Molecular characterization of newcastle disease viruses isolated from rural chicken in northwest ethiopia reveals the circulation of three distinct genotypes in the country. Tropical Animal Health and Production, 2013 Oct 22. [Epub ahead of print]. 15. Ferrara, F., Molesti, E., Böttcher-Friebertshäuser, E., Cattoli, G., Corti, D., Scott, S., et al. (2013). The human transmembrane protease serine 2 is necessary for the production of group 2 influenza A virus pseudotypes. Journal of Molecular and Genetic Medicine, 7, Fouchier, R., García-Sastre, A., Kawaoka, Y., Barclay, W., Bouvier, N. M., Brown, I., et al. (2013, Feb. 1). Transmission studies resume for avian flu. Science, 339(6119), Meseko C, Olaleye D, Capua I, Cattoli G. Swine Influenza in Sub-Saharan - Current Knowledge and Emerging Insights. Zoonoses Public Health Jul 5.doi: /zph Molesti, E., Cattoli, G., Ferrara, F., Böttcher-Friebertshäuser, E., Terregino, C., & Temperton, N. (2013). The production and development of H7 influenza virus pseudotypes for the study of humoral responses against avian viruses. Journal of Molecular and Genetic Medicine, 7, Molesti, E., Milani, A., Terregino, C., Cattoli, G., & Temperton, N. J. (2013). Comparative serological assays for the study of H5 and H7 avian influenza viruses. Influenza Research and Treatment, 2013, doi: /2013/ Epub 2013 Sep Monne, I., Hussein, H. A., Fusaro, A., Valastro, V., Hamoud, M. M., Khalefa, R. A., et al. (2013). H9N2 influenza A virus circulates in H5N1 endemically infected poultry population in egypt. Influenza and Other Respiratory Viruses, 7(3), Monne, I., Yamage, M., Dauphin, G., Claes, F., Ahmed, G., Giasuddin, M., et al. (2013). Reassortant avian influenza A(H5N1) viruses with H9N2-PB1 gene in poultry, Bangladesh. Emerging Infectious Diseases, 19(10), Romero-Tejeda, A., & Capua, I. (2013). Virus-specific factors associated with zoonotic and pandemic potential. Influenza and Other Respiratory Viruses, 7 Suppl 2, Schade, B., Schmitt, F., Bohm, B., Alex, M., Fux, R., Cattoli, G., et al. (2013). Adenoviral gizzard erosion in broiler chickens in germany. Avian Diseases, 57(1), Terregino, C., Aldous, E. W., Heidari, A., Fuller, C. M., De Nardi, R., Manvell, R. J., Beato, M. S., Shell, W. M., Monne, I., Brown, I. H., Alexander, D. J., and Capua, I. Antigenic and genetic analyses of isolate APMV/wigeon/Italy/3920-1/2005 indicate that it represents a new avian paramyxovirus (APMV-12). Arch. Virol. 158: b) International conferences: Bonfante, F., Fusaro, A.,Berton, V., Maniero, S., Vascellari, M., Terregino, C., and Capua, I. (2013). Identification of a virulent H10N1 avian influenza virus with monobasic haemagglutinin cleavage site motif. World Veterinary Poultry Association (WVPA) August Nantes (France) 2. Bonfante, F., Gardin, Y., Terregino, C., Berton, V., Giasuddin, M., Das Bidhan, C., Yamage, M., Palya, V., and Capua, I. (2013). Efficacy of a single dose of rhvt-h5 Avian Influenza vector vaccine against a clade of H5N1 Highly Pathogenic virus. World Veterinary Poultry Association (WVPA) August Nantes (France) 3. Cavicchioli, L., Beffagna, G., Zanetti, R., Mainenti, M., Frezza, F., Bonfante, F., Terregino, C., Zappulli, V., and Capua, I. (2013) Histopathological and immunohistochemical study of exocrine and endocrine pancreatic lesions in avian influenza a experimentally-infected turkeys, ACVP/ASVCP Annual Meeting November 2013, Montrèal (Canada). 8 OIE Reference Laboratory Reports Activities, 2013

9 4. Fusaro, A., Monne, I., Hughes, J., Schivo, A., Salomoni, A., Orton, R., Bonfanti, L., Murcia, P., and Cattoli, G. Convergent evolution of H7 viruses from two distinct epidemics. Epidemics4 - Fourth International Conference on Infectious Disease Dynamics, November 2013, Amsterdam (The Netherlands). 5. Fusaro, A., Monne, I., Hughes, J., Schivo, A., Salomoni, A., Orton, R., Bonfanti, L., Murcia, P., and Cattoli, G. Evolution of H7 viruses in poultry: convergent and divergent mutations. Options for the Control of Influenza VIII, 5-10 September 2013, Cape Town (South ). 6. Kasloff, S., Pizzuto, M., and Capua, I. (2013) Susceptibility of human-origin pancreatic tumor cell lines to influenza virus infection, The 7th International Meeting on Replicating Oncolytic Virus Therapeutics, September, Quebec City (Canada). 7. Kasloff, S., Pizzuto, M., and Capua, I. (2013) Susceptibility of Human-Origin Pancreatic Tumour Cell Lines to Influenza A Virus Infection, Influenza 2013: One Influenza, One World, One Health, September 2013, St Hilda's College, Oxford (UK). 8. Pizzuto, M., Kasloff, S., Benussi, M., Barclay, W., and Capua, I. (2013). Evaluation of oncolytic properties of influenza a virus in human pancreatic adenocarcinoma cells. 5th an Congress of Virology, September 2013, Lyon (France). 9. Pizzuto, MS, Monne, I., Maniero, S., Burattin, A., Beato, M., Valastro, V., Mancin, M., Vicenzi, E., Cattoli, G., and Capua, I. (2013). Evaluation of cross-reactivity of human influenza antibodies against H1, H2 and H3 avian influenza virus subtypes. Proceedings of International Meeting on Emerging Diseases and surveillance, February 2013, Vienna (Austria). 10. Romero Tejeda, A., Aiello, R., Berton, V., Salomoni, A., Vascellari, M., & Cattoli, G. (2013). Susceptibility of bank voles (myodes glareolus) to infection with H5N1 and H7N1 highly pathogenic avian influenza viruses. Options for the Control of Influenza VIII, 5-10 September 2013 Cape Town (South ). 11. Romero Tejeda, A., Aiello, R., Ormelli, S., De Battisti, C., Beffagna, G., Terregino, C., et al. (2013). Establishment of a mouse model to evaluate pancreatic colonization by influenza A viruses and its metabolic consequences. Influenza 2013: One Influenza, One World, One Health Sept. St Hilda's College, Oxford (UK) c) National conferences: 1 1. Terregino, C. Epidemia da H5N2 LPAI LII Convegno annuale Società Italiana di Patologia Aviare (S.I.P.A.), Aprile 2013, Forlì (Italy). d) Other: (Provide website address or link to appropriate information) 2 wcastle&catid=51&itemid=201 ToR: To provide scientific and technical training for personnel from OIE Member Countries To recommend the prescribed and alternative s or vaccines as OIE Standards 14. Did your laboratory provide scientific and technical training to laboratory personnel from other OIE Member Countries? a) Technical visits: 3 b) Seminars: 0 c) Hands-on training courses: 0 d) Internships (>1 month): 5 OIE Reference Laboratory Reports Activities,

10 Type of technical training provided (a, b, c or d) Country of origin of the expert(s) provided with training No. participants from the corresponding country a South 1 a Cuba 1 a Israel 1 d Nigeria 1 d Italy 1 d Ethiopia 1 d Egypt 1 d Turkey 1 ToR: To maintain a system of quality assurance, biosafety and biosecurity relevant for the pathogen and the disease concerned 15. Does your laboratory have a Quality Management System certified according to an International Standard? Quality management system adopted ISO Is your laboratory accredited by an international accreditation body? Test for which your laboratory is accredited HI AGID Virus isolation in embryonated eggs Accreditation body ACCREDIA Italian Accreditation System ACCREDIA Italian Accreditation System ACCREDIA Italian Accreditation System 17. Does your laboratory maintain a biorisk management system for the pathogen and the disease concerned? (See Manual of Diagnostic Tests and Vaccines for Terrestrial Animals 2012, Chapter or Manual of Diagnostic Tests for Aquatic Animals 2012, Chapter 1.1.1) 10 OIE Reference Laboratory Reports Activities, 2013

11 ToR: To organise and participate in scientific meetings on behalf of the OIE 18. Did your laboratory organise scientific meetings on behalf of the OIE? No 19. Did your laboratory participate in scientific meetings on behalf of the OIE? Title of event Date (mm/yy) Location Role (speaker, presenting poster, short communications) Title of the work presented WHO Consultation on the Composition of Influenza Vaccines for the Southern Emisphere 09/13 Geneva, Switzerland Speaker Presentation of OFFLU genetic and antigenetic data Technical meeting on Avian Influenza Hatchery Vaccination (OFFLU) 12/13 Beijing, China Speaker Lessons on HPAI vaccination as a control and preventive tool ToR: To establish and maintain a network with other OIE Reference Laboratories designated for the same pathogen or disease and organise regular inter-laboratory proficiency ing to ensure comparability of results 20. Did your laboratory exchange information with other OIE Reference Laboratories designated for the same pathogen or disease? 21. Was your laboratory involved in maintaining a network with OIE Reference Laboratories designated for the same pathogen or disease by organising or participating in proficiency s? Purpose of the proficiency s: 1 Role of your Reference Laboratory (organiser/ participant) No. participants Participating OIE Ref. Labs/ organising OIE Ref. Lab. OFFLU Proficiency Test on AI and ND Participants Information available from organiser (APHIS.USDA) Information available from organiser (APHIS.USDA) an Proficiency Test on AI and ND Participants Information available from organiser (AHVLA, UK) Information available from organiser (AHVLA, UK) 1 validation of a diagnostic protocol: specify the ; quality control of vaccines: specify the vaccine type, etc. OIE Reference Laboratory Reports Activities,

12 22. Did your laboratory collaborate with other OIE Reference Laboratories for the same disease on scientific research projects for the diagnosis or control of the pathogen of interest? Title of the project or contract Scope Name(s) of relevant OIE Reference Laboratories EMIDA ERA-Net Epi-Seq Molecular epidemiology of epizootic diseases using next generation sequencing technology Friedrich-Loeffler-Institut (Germany) ANIHWA- NADIV Cooperation and coordination of National Research Programmes on Animal Health and Welfare of farm animals, including fish and bees Kimron Veterinary Institute (Israel);SVA-Statens Veterinamedicinska Anstalt (Sweden) EPIZONE Prevention and control of Animal Diseases Friedrich-Loeffler-Institut (Germany);Veterinamedicinska Anstalt (Sweden);Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia Romagna ToR: To organise inter-laboratory proficiency ing with laboratories other than OIE Reference Laboratories for the same pathogens and diseases to ensure equivalence of results 23. Did your laboratory organise or participate in inter-laboratory proficiency s with laboratories other than OIE Reference Laboratories for the same disease? Note: See Interlaboratory comparisons in: Laboratory Proficiency Testing at: see point 1.3 Purpose for inter-laboratory comparisons 1 No. participating laboratories Region(s) of participating OIE Member Countries FAO Proficiency for Avian Influenza and Newcastle Disease (organiser) 8 Asia and Pacific Middle East National Proficiency Test for Avian Influenza and Newcastle Disease (organiser) 15 Asia and Pacific Middle East 12 OIE Reference Laboratory Reports Activities, 2013

13 ToR: To place expert consultants at the disposal of the OIE 24. Did your laboratory place expert consultants at the disposal of the OIE? Kind of consultancy Location Subject (facultative) OFFLU Expert to WHO VCM Geneva Consultation on the Composition of Influenza Vaccines for the Southern Emisphere Executive Committee OFFLU Paris OFFLU 25. Additional comments regarding your report: Publishing: Capua, I., and Alexander, D. J. Influenza aviaire et maladie de Newcastle. Un manuel de terrain et de laboratoire. Springer. March In question 10: Did your laboratory participate in international scientific studies in collaboration with OIE Member Countries other than the own? One of the countries listed as being involved in the study entitled "FP7-FLUPIG" is CHINA (PEOPLE'S REP. OF). We would like specify that the participants were from Hong Kong (special administrative region of China). OIE Reference Laboratory Reports Activities,