Supporting Information. Dynamic Proteome Alteration and Functional Modulation of. Human Saliva Induced by Dietary Chemosensory Stimuli

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1 Supporting Information Dynamic Proteome Alteration and Functional Modulation of Human Saliva Induced by Dietary Chemosensory Stimuli Matthias Bader 1, Andreas Dunkel 1, Mareike Wenning 2, Bernd Kohler 2, Guillaume Medard 3, Estela del Castillo 3, Amin Gholami 3, Bernhard Kuster 3, Siegfried Scherer 2,4, and Thomas Hofmann 1,2,5 * 1 Chair of Food Chemistry and Molecular Sensory Science, Technische Universität München, Lise- Meitner Str. 34, D Freising, Germany, 2 ZIEL Institute for Food and Health, Technische Universität München, D Freising, Germany, 3 Chair of Proteomics and Bioanalytics, Technische Universität München, Emil-Erlenmeyer-Forum 5, D Freising, Germany, 4 Chair of Microbial Ecology, Department of Biosciences, WZW, Technische Universität München, Freising, Germany, 5 Leibniz-Institute for Food Systems Biology at the Technical University of Munich, Lise-Meitner Str. 34, D Freising, Germany.

2 Table S1: Identified Proteins, Uniprot identifier, NSAF before stimulation (t 0 ) and after stimulation (t 15 -t 75 ) with S1 (citric acid) and p-values. Identified Proteins Uniprot Identifier t 0 NSAF (±SD) t 15 t 45) t 75 Isoform 1 of Interleukin-1 receptor antagonist protein IL1RA_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Kallikrein-14 KLK14_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Peroxiredoxin-1 PRDX1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of Kallikrein-11 KLK11_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Cystatin-D CYTD_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Heat shock 70 kda protein 4 HSP74_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) HSPA5 protein GRP78_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Transmembrane protease, serine 11D TM11D_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of Sulfhydryl oxidase 1 QSOX1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Rho GDP-dissociation inhibitor 2 GDIR2_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of Heat shock cognate 71 kda protein HSP7C_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Ly6/PLAUR domain-containing protein 3 LYPD3_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Polymeric immunoglobulin receptor PIGR_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Beta-2-microglobulin B2MG_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Neutrophil defensin 1 DEF1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) F-actin-capping protein subunit alpha-1 CAZA1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) cdna FLJ53019, highly similar to Serpin B13 SPB13_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Protein S100-A8 S10A8_HUMAN (± ) (± ) / ( ) (± ) / ( (± ) / ( ) Isoform H17 of Myeloperoxidase PERM_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Kallikrein-13 KLK13_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Fatty acid-binding protein, epidermal FABP5_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Antileukoproteinase SLPI_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of Nucleobindin-2 NUCB2_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Lipocalin-1 LCN1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Protein Plunc BPIA1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Coronin-1A COR1A_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Ras-related C3 botulinum toxin substrate 2 RAC2_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Putative uncharacterized protein Q86Z22_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Plastin-2 PLSL_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Chloride intracellular channel protein 1 CLIC1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Cathepsin D CATD_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) cdna FLJ61407, highly similar to Involucrin INVO_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Cofilin-1 COF1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Histatin-1 HIS1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform Sap-mu-0 of Proactivator polypeptide SAP_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Prominin-1 PROM1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Cathepsin L1 CATL1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Cystatin-SA CYTT_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Alpha-actinin-4 ACTN4_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of protein sigma 1433S_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Protein S100-A11 S10AB_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Protein S100-P S100P_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Ceruloplasmin CERU_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) cdna FLJ25678 fis, clone TST04067, highly similar to PURINE PNPH_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) NUCLEOSIDE PHOSPHORYLASE Furin FURIN_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Histone H2B type 1-L H2B1L_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Dipeptidyl peptidase 4 DPP4_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Lysozyme C LYSC_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( )

3 Isoform 1 of Myosin-9 MYH9_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Plasminogen PLMN_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) protein zeta/delta 1433Z_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Actin, alpha skeletal muscle ACTS_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Actin, cytoplasmic 1 ACTB_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Cystatin-B CYTB_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Apolipoprotein A-I APOA1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of Fibrinogen alpha chain FIBA_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform Gamma-B of Fibrinogen gamma chain FIBG_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of Serpin B3 SPB3_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Azurocidin CAP7_HUMAN (± )) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of Fibronectin FINC_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Alpha-1-acid glycoprotein 1 A1AG1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Transthyretin TTHY_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Putative uncharacterized protein ALB Q56G89_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Serotransferrin TRFE_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Hemopexin HEMO_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Alpha-1B-glycoprotein A1BG_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Prolactin-inducible protein PIP_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Submaxillary gland androgen-regulated protein 3B SMR3B_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Galectin-3-binding protein LG3BP_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Annexin A3 ANXA3_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform Mitochondrial of Peroxiredoxin-5, mitochondrial PRDX5_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Lactoperoxidase PERL_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Eosinophil cationic protein ECP_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Heat shock protein beta-1 HSPB1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) cdna FLJ55716, highly similar to Desmocollin-2 DSC2_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Epithelial cadherin CADH1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Myosin-1 MYH1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Puromycin-sensitive aminopeptidase PSA_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of Attractin ATRN_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Macrophage-capping protein CAPG_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Peroxiredoxin-2 PRDX2_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Myeloblastin PRTN3_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Leukocyte elastase inhibitor ILEU_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Protein S100-A9 S10A9_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Protein S100-A6 S10A6_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Glucose-6-phosphate isomerase G6PI_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Matrix metalloproteinase-9 MMP9_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Leukocyte elastase ELNE_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Cathepsin G CATG_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Matrix Gla protein MGP_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Monocyte differentiation antigen CD14 CD14_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of Complement factor H CFAH_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Desmoglein-3 DSG3_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Complement C4-A CO4A_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Metalloproteinase inhibitor 1 TIMP1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Cystatin-C CYTC_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Cystatin-S CYTS_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Cystatin-A CYTA_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Uncharacterized protein UNQ773/PRO1567 ZG16B_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Protein S100-A16 S10AG_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Calmodulin CALM_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Histone H2A type 1-H H2A1H_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Small proline-rich protein 3 SPRR3_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of Deleted in malignant brain tumors 1 protein DMBT1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( )

4 Mucin-7 MUC7_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) alpha-2-glycoprotein 1, zinc ZA2G_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) FLJ00385 protein (Fragment) Q8NF17_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Phosphoglycerate kinase 1 PGK1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Golgi membrane protein 1 GOLM1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of Collagen alpha-1(xiv) chain COEA1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) peptidylglycine alpha-amidating monooxygenase isoform a preproprotein AMD_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) immunoglobulin J chain IGJ_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform GN-1L of Glycogenin-1 GLYG_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Carbonic anhydrase 1 CAH1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Cellular retinoic acid-binding protein 2 RABP2_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Thioredoxin THIO_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Profilin-1 PROF1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Calmodulin-like protein 3 CALL3_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Histone H1.2 H12_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Histone H1.5 H15_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) cdna FLJ55792, highly similar to L-lactate dehydrogenase A chain LDHA_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Protein S100-A12 S10AC_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Superoxide dismutase [Cu-Zn] SODC_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Annexin A1 ANXA1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Glyceraldehyde-3-phosphate dehydrogenase G3P_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Glutaredoxin-1 GLRX1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) L-lactate dehydrogenase B chain LDHB_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Moesin MOES_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Phosphatidylethanolamine-binding protein 1 PEBP1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) 6-phosphogluconate dehydrogenase, decarboxylating 6PGD_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Glutathione S-transferase P GSTP1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Protein S100-A7 S10A7_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Alcohol dehydrogenase [NADP+] AK1A1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform M1 of Pyruvate kinase isozymes M1/M2 KPYM_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Malate dehydrogenase, cytoplasmic MDHC_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Malate dehydrogenase, mitochondrial MDHM_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Collagen alpha-1(vi) chain CO6A1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of Vinculin VINC_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Clusterin CLUS_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of Long palate, lung and nasal epithelium carcinomaassociated BPIB1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) protein 1 Isoform 1 of WAP four-disulfide core domain protein 2 WFDC2_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Cathelicidin antimicrobial peptide precursor CAMP_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) cdna FLJ60163, highly similar to Carbonic anhydrase 6 CAH6_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Thrombospondin-1 TSP1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Aldehyde dehydrogenase, dimeric NADP-preferring AL3A1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Bactericidal/permeability-increasing protein-like 1 BPIB2_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of Granulins GRN_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) SPARC-like protein 1 SPRL1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Cornulin CRNN_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Putative uncharacterized protein CLCA4 A8MQC9_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Fibrinogen beta chain FIBB_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Beta-mannosidase MANBA_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Beta-2-glycoprotein 1 APOH_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Growth-inhibiting protein 12 TRFL_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Neutrophil gelatinase-associated lipocalin NGAL_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Transcobalamin-1 TCO1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Protein-glutamine gamma-glutamyltransferase E TGM3_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Alpha-amylase 1 AMY1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) ATP synthase subunit beta, mitochondrial ATPB_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( )

5 Short palate, lung and nasal epithelium carcinoma-associated protein 2 BPIA2_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Kallikrein-1 KLK1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Heat shock 70 kda protein 1 HSP71_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Cystatin-SN CYTN_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Delta and Notch-like epidermal growth factor-related receptor DNER_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform Non-muscle of Myosin light polypeptide 6 MYL6_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Uncharacterized protein C6orf58 CF058_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Ig lambda chain V-I region WAH LV106_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) ERO1-like protein alpha ERO1A_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) cdna FLJ14473 fis, clone MAMMA , highly similar to Homo Q96K68_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) sapiens SNC73 protein (SNC73) mrna Hemoglobin subunit alpha HBA_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Protein FAM25 FM25A_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 2 of Golgi apparatus protein 1 GSLG1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Uncharacterized protein C4orf40 CD040_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of Ribonuclease T2 RNT2_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) annexin A2 isoform 1 ANXA2_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Alpha-2-macroglobulin-like protein 1 A2ML1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Peptidyl-prolyl cis-trans isomerase A PPIA_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Putative uncharacterized protein DKFZp686C15213 Q6MZU6_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Histone H4 H4_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of Triosephosphate isomerase Q53HE2_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform alpha-enolase of Alpha-enolase ENOA_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Fructose-bisphosphate aldolase A ALDOA_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Hemoglobin subunit delta HBD_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Alpha-2-macroglobulin A2MG_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Kallikrein-10 KLK10_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) IGLV3-25 protein Q5NV90_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Transgelin-2 TAGL2_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Putative uncharacterized protein KV206_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) cdna FLJ35730 fis, clone TESTI , highly similar to ALPHA-1- AACT_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) ANTICHYMOTRYPSIN Isoform 1 of Alpha-1-antitrypsin A1AT_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) 47 kda protein HPT_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Phospholipid transfer protein, isoform CRA_c B3KUE5_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) cdna FLJ54957, highly similar to Transketolase TKT_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) HEBP2 protein (Fragment) HEBP2_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Ubiquitin-like modifier-activating enzyme 1 UBA1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Peptidyl-prolyl cis-trans isomerase B PPIB_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 2 of Gelsolin GELS_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Hemoglobin subunit beta HBB_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Transaldolase TALDO_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of Serum albumin ALBU_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Secreted frizzled-related protein 1 SFRP1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) actinin, alpha 1 isoform a ACTN1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Glycogen phosphorylase, liver form PYGL_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Serpin B5 SPB5_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Complement C3 (Fragment) CO3_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) cdna FLJ41981 fis, clone SMINT , highly similar to Protein Tro Q6ZVX0_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) alpha1 H,myeloma Ubiquitin C splice variant Q5UGI3_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Rheumatoid factor D5 light chain (Fragment) A0N5G5_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Bactericidal permeability-increasing protein BPI_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) IGL@ protein Q6GMW4_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Rheumatoid factor C6 light chain (Fragment) A0N5G1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Ezrin EZRI_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( )

6 mucin 5, subtype B, tracheobronchial MUC5B_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) proline rich 4 (lacrimal) isoform 1 B4E2K9_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Lactoferrin E7ER44_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( )

7 Table S2: Identified Proteins, Uniprot identifier, NSAF before stimulation (t 0 ) and after stimulation (t 15 -t 75 ) with S2 (aspartame) and p-values. Identified Proteins Uniprot Identifier t 0 NSAF (±SD) t 15 t 45 t 75 Isoform 1 of Interleukin-1 receptor antagonist protein IL1RA_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Pro-epidermal growth factor EGF_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Peroxiredoxin-1 PRDX1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of Apoptosis-associated speck-like protein containing a CARD ASC_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Cathepsin Z CATZ_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of Kallikrein-11 KLK11_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Cystatin-D CYTD_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Heat shock 70 kda protein 4 HSP74_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) HSPA5 protein GRP78_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Transmembrane protease, serine 11D TM11D_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of Sulfhydryl oxidase 1 QSOX1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Rho GDP-dissociation inhibitor 2 GDIR2_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of Heat shock cognate 71 kda protein HSP7C_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Ly6/PLAUR domain-containing protein 3 LYPD3_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Polymeric immunoglobulin receptor PIGR_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Beta-2-microglobulin B2MG_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Actin-related protein 2/3 complex subunit 3 ARPC3_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Neutrophil defensin 1 DEF1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) F-actin-capping protein subunit alpha-1 CAZA1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Resistin RETN_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Protein S100-A8 S10A8_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform H17 of Myeloperoxidase PERM_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Fatty acid-binding protein, epidermal FABP5_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Alpha-N-acetylglucosaminidase ANAG_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of Nucleobindin-2 NUCB2_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Lipocalin-1 LCN1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Protein Plunc BPIA1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Coronin-1A COR1A_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of Acyl-CoA-binding protein ACBP_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Putative uncharacterized protein Q86Z22_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Plastin-2 PLSL_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Chloride intracellular channel protein 1 CLIC1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Cathepsin D CATD_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) cdna FLJ61407, highly similar to Involucrin INVO_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Cofilin-1 COF1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Histatin-1 HIS1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Prominin-1 PROM1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Cystatin-SA CYTT_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Alpha-actinin-4 ACTN4_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of protein sigma 1433S_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Protein S100-A11 S10AB_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Ras-related protein Rab-7a RAB7A_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Protein S100-P S100P_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Ceruloplasmin CERU_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) cdna FLJ25678 fis, clone TST04067, highly similar to PURINE PNPH_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) NUCLEOSIDE PHOSPHORYLASE Dipeptidyl peptidase 4 DPP4_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Lysozyme C LYSC_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Chitinase-3-like protein 2 CH3L2_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( )

8 cdna FLJ55673, highly similar to Complement factor B Q53F89_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) protein zeta/delta 1433Z_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Actin, cytoplasmic 1 ACTB_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Calmodulin-like protein 5 CALL5_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Cystatin-B CYTB_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Apolipoprotein A-I APOA1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Apolipoprotein A-II APOA2_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform Gamma-B of Fibrinogen gamma chain FIBG_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of Serpin B3 SPB3_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Azurocidin CAP7_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of Fibronectin FINC_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Alpha-1-acid glycoprotein 1 A1AG1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Transthyretin TTHY_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Serotransferrin TRFE_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Hemopexin HEMO_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Alpha-1B-glycoprotein A1BG_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Prolactin-inducible protein PIP_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Submaxillary gland androgen-regulated protein 3B SMR3B_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Galectin-3-binding protein LG3BP_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform Mitochondrial of Peroxiredoxin-5, mitochondrial PRDX5_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Lactoperoxidase PERL_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) cdna FLJ55716, highly similar to Desmocollin-2 DSC2_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Epithelial cadherin CADH1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Puromycin-sensitive aminopeptidase PSA_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Filaggrin FILA_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of Attractin ATRN_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Macrophage-capping protein CAPG_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Peroxiredoxin-2 PRDX2_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Myeloblastin PRTN3_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Leukocyte elastase inhibitor ILEU_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Protein S100-A9 S10A9_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Protein S100-A6 S10A6_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Matrix metalloproteinase-9 MMP9_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Leukocyte elastase ELNE_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Neutrophil collagenase MMP8_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Desmoglein-3 DSG3_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Complement C4-A CO4A_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Metalloproteinase inhibitor 1 TIMP1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Cystatin-C CYTC_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Cystatin-S CYTS_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Protein S100-A4 S10A4_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Cystatin-A CYTA_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Protein FAM3D FAM3D_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Uncharacterized protein UNQ773/PRO1567 ZG16B_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Secretoglobin family 3A member 1 SG3A1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Histone H2A type 1-H H2A1H_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Small proline-rich protein 3 SPRR3_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of Deleted in malignant brain tumors 1 protein DMBT1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Aldo-keto reductase family 1 member B10 AK1BA_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Mucin-7 MUC7_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Histone H2B type 1-D H2B1D_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) IGL@ protein LAC2_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 2 of Endoplasmic reticulum aminopeptidase 1 ERAP1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) alpha-2-glycoprotein 1, zinc ZA2G_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) FLJ00385 protein (Fragment) Q8NF17_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Phosphoglycerate kinase 1 PGK1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( )

9 Golgi membrane protein 1 GOLM1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of Collagen alpha-1(xiv) chain COEA1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) peptidylglycine alpha-amidating monooxygenase isoform a preproprotein AMD_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) immunoglobulin J chain IGJ_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) ubiquitin and ribosomal protein S27a precursor RS27A_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) ADP-ribosylation factor 1 ARF1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Carbonic anhydrase 1 CAH1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Thioredoxin THIO_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Profilin-1 PROF1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Calmodulin-like protein 3 CALL3_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) cdna FLJ55792, highly similar to L-lactate dehydrogenase A chain LDHA_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Annexin A1 ANXA1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Glyceraldehyde-3-phosphate dehydrogenase G3P_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Glutaredoxin-1 GLRX1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) L-lactate dehydrogenase B chain LDHB_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Moesin MOES_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Phosphatidylethanolamine-binding protein 1 PEBP1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) 6-phosphogluconate dehydrogenase, decarboxylating 6PGD_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Glutathione S-transferase P GSTP1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Protein S100-A7 S10A7_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Alcohol dehydrogenase [NADP+] AK1A1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Peroxiredoxin-6 PRDX6_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 2 of Serpin B13 SPB13_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform M1 of Pyruvate kinase isozymes M1/M2 KPYM_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) IgGFc-binding protein FCGBP_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) PDCD6IP protein PDC6I_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Malate dehydrogenase, cytoplasmic MDHC_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Malate dehydrogenase, mitochondrial MDHM_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Collagen alpha-1(vi) chain CO6A1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of Vinculin VINC_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Clusterin CLUS_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of Long palate, lung and nasal epithelium carcinomaassociated BPIB1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) protein 1 Isoform 1 of Arginase-1 ARGI1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Plasma protease C1 inhibitor IC1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Cathelicidin antimicrobial peptide precursor CAMP_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Macrophage migration inhibitory factor MIF_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) cdna FLJ60163, highly similar to Carbonic anhydrase 6 CAH6_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Aldehyde dehydrogenase, dimeric NADP-preferring AL3A1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Bactericidal/permeability-increasing protein-like 1 BPIB2_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Isoform 1 of Granulins GRN_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Cornulin CRNN_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Fibrinogen beta chain FIBB_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Beta-mannosidase MANBA_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Growth-inhibiting protein 12 TRFL_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Neutrophil gelatinase-associated lipocalin NGAL_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Transcobalamin-1 TCO1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Protein-glutamine gamma-glutamyltransferase E TGM3_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Alpha-amylase 1 AMY1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) cdna FLJ59142, highly similar to Epididymal secretory protein E1 E7EMS2_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Protein FAM49B FA49B_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Short palate, lung and nasal epithelium carcinoma-associated protein 2 BPIA2_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Kallikrein-1 KLK1_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Heat shock 70 kda protein 1 HSP71_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Cystatin-SN CYTN_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( ) Prostasin PRSS8_HUMAN (± ) (± ) / ( ) (± ) / ( ) (± ) / ( )