Gene Expression Multiplexing Menu

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1 Gene Expression Multiplexing Menu Mouse Rat Human

2 Table of CONTENTS Mouse Inflammatory Plex 2 Rat Stress Plex 3 Growth Regulation Plex 4 Multitox Plex 5 Pharma III Plex 6 Reference Plex 7 Human Transporter Plex 8 Pharma III Plex 9 Inflamamatory Plex 10 Growth Regulation Plex 11 Immunotox Plex 12 Multitox Plex 13 Reference Plex 14 Breast Cancer Plex 15 Multitox Plex 16 1

3 Mouse Inflammatory Plex Mouse Inflammatory Plex 1 Actin, beta (ACTB) X Tumor necrosis factor (Tnf) NM_ Interleukin-6 (IL-6) X Membrane cofactor protein (Mcp) NM_ Matrix metalloproteinase 9 (Mmp9) NM_ Interferon-gamma inducing factor (IL-18) D Interferon-inducible protein 10 receptor (Cxcr3, C-X-C) AB Platelet-derived growth factor-inducible KC protein (Cxcl1) J Interleukin 4 (Il-4) M Interleukin 12b (Il12b) NM_ Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) NM_ Macrophage colony-stimulating factor (Csf) M Chemokine (C-C motif) receptor 2 (Ccr2) NM_ Connective tissue growth factor (Ctgf) NM_ Transcription factor NF-kappa-B DNA binding subunit M Interleukin 10 (IL-10) M Interleukin 1 beta (Il1b) NM_ Fibroblast growth factor 1 (Fgf1) NM_ Interferon gamma (Ifng) NM_ T-cell activation gene 3 (TCA3, CCl1, C-C) M Kanmycin Resistant 22 Peptidylprolyl isomerase A (Ppia / Cyclophillin A) X Signal transducer and activator of transcription 1 (Stat1) NM_ Interferon regulatory factor 1 (Irf-1) M

4 Rat Stress Plex Rat Stress Plex 1 Glutathione reductase (Gsr) NM_ ATPase inhibitory factor 1 (Atpif1) NM_ Cyclin-dependent kinase inhibitor 1A, (p21/waf1) U Glutamate cysteine ligase, modifier subunit (Gclm) NM_ Thioredoxin reductase(txnr1) U Topoisomerase (DNA) 2 alpha (Top2a) NM_ DnaJ (Hsp40) homolog, subfamily B, member 4 (Dnajb4) NM_ Heat shock 10 kda protein 1 (Hspe1) NM_ Ornithine transcarbamylase (Otc) NM_ Heme oxygenase (HMOX-1) J Heat shock 70kD protein 1A (Hspa1a) NM_ Solute carrier family 10 (sodium/bile acid cotransporter family), member 1 (Slc10a1) NM_ Heat shock 90kDa protein 1, beta (Hspcb) NM_ Peptidylprolyl isomerase A (Ppia / Cyclophillin A) NM_ Glutathione S-transferase, mu type 3 (Gstm3) NM_ Bcl2-associated athanogene 3 (Bag3) NM_ Heat shock factor binding protein 1 (Hsbp1) NM_ Hypoxia up-regulated 1 (Hyou1) NM_ Actin, beta (ACTB) NM_ Kanmycin Resistant 21 Biliverdin reductase B (flavin reductase (NADPH)) (Blvrb) XM_ Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) NM_ Cytochrome P450, 1a1 (Cyp1a1) NM_

5 Rat Multitox Plex Rat Multitox Plex 1 Cyclophilin A NM_ Cytochrome4A1 (CYP4A22) NM_ Cytochrome2B1 J Cytochrome3A1 L Cytochrome2E1 NM_ Cytochrome P-450 M1 (CYP2C9 orthologue) J Cytochrome 2D22 (human CYP2D6 homolog) NM_ NADPH cytochrome P-450 reductase M UDP-glucuronosyltransferase NM_ Aldehyde dehydrogenase AF Cyclin dependent kinase inhibitor 1A (p21) U Cytochrome P450 (PB1) 2C19 orthologue M Heme Oxygenase (Hmox1) NM_ NAD(P)H dehydrogenase quinone 1 NM_ Growth arrest DNA damage 153 (Gadd153) U Cyclooxygenase-2 S Growth arrest DNA damage 45 L Apoptosis related cysteine protease NM_ CyclinD1 (Ccnd1) NM_ Proliferating cell nuclear antigen NM_ Tumor protein p53 NM_ Cytochrome 1A2 K Actin, beta (ACTB) NM_ Kanmycin Resistant 25 TSC22 L Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) NM_ Cytochrome1A1 NM_

6 Rat Growth Regulation Plex Rat Growth Regulation Plex 1 Cyclophilin A NM_ Cytochrome4A1 (CYP4A22) NM_ Cytochrome2B1 J Cytochrome3A1 L Cytochrome2E1 NM_ Cytochrome P-450 M1 (CYP2C9 orthologue) J Cytochrome 2D22 (human CYP2D6 homolog) NM_ NADPH cytochrome P-450 reductase M UDP-glucuronosyltransferase NM_ Aldehyde dehydrogenase AF Cyclin dependent kinase inhibitor 1A (p21) U Cytochrome P450 (PB1) 2C19 orthologue M Heme Oxygenase (Hmox1) NM_ NAD(P)H dehydrogenase quinone 1 NM_ Growth arrest DNA damage 153 (Gadd153) U Cyclooxygenase-2 S Growth arrest DNA damage 45 L Apoptosis related cysteine protease NM_ CyclinD1 (Ccnd1) NM_ Proliferating cell nuclear antigen NM_ Tumor protein p53 NM_ Cytochrome 1A2 K Actin, beta (ACTB) NM_ Kanmycin Resistant 25 TSC22 L Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) NM_ Cytochrome1A1 NM_

7 Rat Pharma III Plex Rat Pharma III Plex 1 Cytochrome P450, family 2, subfamily b, (CYP2B2) polypeptide 2 XM_ Glutathione-S-transferase, pi 1 (Gstp1) NM_ CyclinE1 D CyclinG1 X Trefoil factor 1 (Tff1) NM_ Insulin-like growth factor binding protein 5 (IGFBP-5) M Cytochrome P450, subfamily IIA (phenobarbital-inducble)/ (Cytochrome P450 IIA3) (Cyp2a3a) NM_ Cytochrome P450, family 1, subfamily b, polypeptide 1 (Cyp1b1) NM_ Peroxisome proliferator activated receptor alpha(ppara) M Myelocytomatosis viral oncogene homolog (avian) (c-myc) AY Cytochrome P450, subfamily 3A, polypeptide 3 (Cyp3a3) NM_ Cytochrome P450, family 1, subfamily a, (CYP1A2) polypeptide 2 K Baculoviral IAP repeat-containing 5 (Birc5/survivin) AF Peptidylprolyl isomerase A (Ppia / Cyclophillin A) NM_ ATP-binding cassette, sub-family B (MDR/TAP), (Abcb1) member 1 AY Myeloblastosis oncogene-like 1 (MYB) XM_ Cytochrome P450, family 3, subfamily a, (Cyp3a13) polypeptide 13 NM_ Actin, beta (ACTB) NM_ Kanmycin Resistant 20 Cytochrome P450, family 2, subfamily d, (Cyp2d13) polypeptide 13 NM_ Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) NM_

8 Rat Reference Plex Rat Reference Plex 1 Beta-glucuronidase M Ribosomal protein L37a (RPL37A) X Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) NM_ Ca2-activated neutral protease large subunit BC ATP synthase NM_ Nuclear factor NF45 XM_ Glycerol kinase NM_ QRSHs glutaminyl-trna synthetase NM_ kDa Alu RNA binding protein XM_ Histone deacetylase HD1 XM_ Ezrin AF Transferrin Receptor M Proteasome subunit Y BC Transcription Factor IID XM_ MLN51 AF Lysosomal hyaluronidase AF Acidic Ribosomal Protein BC Elongation factor EF-1-alpha BC Hypoxanthine ribosyl transferase M Beta 2 microglobulin NM_ Peptidylprolyl isomerase A (Ppia / Cyclophillin A) NM_ Actin, beta (ACTB) NM_ E2 Ubiquitin conjugating enzyme UbcH5B U s-rRNA M Kanmycin Resistant 7

9 Human Transporter Plex Human Transporter Plex 1 Bile salt export pump (BSEP, ABCB11 ) AF Glutathione transferase M1B (GSTM1) J ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1) NM_ Glutathione S-transferase A1 (GSTA1) NM_ Glutathione S-transferase pi (GSTP1) NM_ Peptidylprolyl isomerase A (Ppia / Cyclophillin A) BC ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (ABCC4) NM_ Solute carrier organic anion transporter family, member 1B3 (SLCO1B3, OATP8) NM_ ATP-binding cassette, sub-family B (MDR/TAP), member 4 (ABCB4) NM_ Human peptide transporter (HPEPT1, SLC15A1 ) U Organic cation transporter 1 (hoct1) U Solute carrier organic anion transporter family, member 1A2 (SLCO1A2, OATP-A) BC Organic anion transporter OATP-C (SLCO1B1) AB ATP-binding cassette, sub-family C (CFTR/MRP), member 5 (ABCC5 ) AB Na/taurocholate cotransporting polypeptide (NTCP, SLC10A1) L Actin, beta (ACTB) NM_ Glutathione S-transferase A2 (GSTA2) NM_ Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) NM_ O-6-methylguanine-DNA methyltransferase (MGMT) NM_ Multidrug resistance-associated protein (MRP, ABCC1) L ATP-binding cassette, sub-family C (CFTR/MRP), member 2 (ABCC2) NM_ Breast cancer resistance protein (BCRP, ABCG2) AF Kanmycin Resistant 24 Multidrug resistance-associated protein 3 (MRP3, ABCC3) AF Solute carrier family 2 (facilitated glucose transporter), member 1 (GLUT1, SLC2A1) NM_ DNA Topoisomerase I J

10 Human Pharma III Plex Human Pharma III Plex 1 Cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6) NM_ Cytochrome P450, family 1, subfamily B, polypeptide 1 (CYP1B1) NM_ ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1) NM_ Cytochrome P450 PCN3 (CYP3A5) J Glutathione S-transferase pi (GSTP1) NM_ V-myb myeloblastosis viral oncogene homolog(myb) NM_ Peptidylprolyl isomerase A (Ppia / Cyclophillin A) BC Baculoviral IAP repeat-containing 5 (survivin) (BIRC5) NM_ Cytochrome P450, family 2, subfamily B, polypeptide 6 (CYP2B6) NM_ Cytochrome P450, family 2, subfamily A, polypeptide 6 (CYP2A6) NM_ V-myc myelocytomatosis viral oncogene homolog BC Cyclin E1 (CCNE1), transcript variant 2 NM_ Peroxisome proliferative activated receptor, alpha (PPARA) NM_ Cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4) NM_ Insulin-like growth factor binding protein 5 (IGFBP5) NM_ Cyclin G1 (CCNG1) NM_ Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) NM_ Cytochrome P450, family 1, subfamily A, polypeptide 2 (CYP1A2) Z Actin, beta (ACTB) NM_ Trefoil factor 1 (TFF1) NM_ Kanmycin Resistant 9

11 Human Inflamamatory Plex Human Inflamamatory Plex 1 CD63 antigen (melanoma 1 antigen) (CD63) NM_ Interleukin 2 (IL2) NM_ Hybridoma growth factor (interleukin 6) (IL6) M Interleukin 8 (IL8) NM_ Tumor necrosis factor (TNF superfamily, member 2) (TNF) NM_ Interferon regulatory factor 1(IRF1) X Peptidylprolyl isomerase A (Ppia / Cyclophillin A) BC Interleukin 4 (IL4) NM_ Monocyte chemoattractant protein 1 receptor (MCP-1RB) U Colony stimulating factor 1 (macrophage) (CSF1) NM_ Type IV collagenase,matrix metallopeptidase 9 (MMP9) J Interleukin 10 (IL10) NM_ Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) (NFKB1) NM_ Monocyte interleukin 1 (IL-1) NM_ Signal transducer and activator of transcription 1, 91kDa (STAT1) NM_ Fibroblast growth factor 1 (acidic) (FGF1) NM_ Connective tissue growth factor (CTGF) NM_ Chemokine (C-C motif) ligand 1 (CCL1) NM_ Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) NM_ Chemokine (C-X-C motif) receptor 3 (CXCR3) X Actin, beta (ACTB) NM_ Membrane cofactor protein (CD46) (MCP1) NM_ Interleukin 18 (interferon-gamma-inducing factor) (IL18) NM_ Kanmycin Resistant 25 Interferon, gamma (IFNG) NM_ Interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) (IL12B) NM_

12 Human Growth Regulation Plex Human Growth Regulation Plex 1 Thymidine kinase (TK1) K B-cell CLL/lymphoma 2 (BCL2) M Caspase 3, apoptosis-related cysteine peptidase (CASP3) NM_ ATPase family, AAA domain containing 3A (ATAD3A) NM_ Tumor necrosis factor (TNF superfamily, member 2) (TNF) NM_ Polymerase (DNA directed), epsilon 2 (p59 subunit) (POLE2) NM_ BCL2-antagonist/killer 1 (BAK1) BC Peptidylprolyl isomerase A (Ppia / Cyclophillin A) BC Cell death-inducing DFFA-like effector a (CIDEA) NM_ Transforming growth factor-beta (TGF-beta) X Ataxia telangiectasia mutated (ATM) NM_ Calmodulin-like 3 (CALML3) BC Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (MDM2) NM_ Tumor necrosis factor receptor superfamily, member 6 (TNFRSF6) (FAS) NM_ Ribonucleotide reductase M2 polypeptide (RRM2) X Ataxia telangiectasia and Rad3 related (ATR) NM_ Cyclin-dependent kinase 2 (CDK2) NM_ Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) NM_ V-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) (MAF) NM_ Actin, beta (ACTB) NM_ Mitogen-activated protein kinase kinase kinase 7 (MAP3K7) NM_ BCL2-associated X protein (BAX) BC Kanmycin Resistant 24 DNA-dependent protein kinase catalytic subunit (PRKDC) U

13 Human Immunotox Plex Human Immunotox Plex 1 Colony stimulating factor 2 (granulocyte-macrophage) (GMCSF) NM_ CD4 antigen (p55) (CD4) NM_ Cytochrome P450, family 1, subfamily A, polypeptide 2 (CYP1A2) NM_ Cytochrome P450, family 1, subfamily B, polypeptide 1 (CYP1B1) NM_ Caspase 3, apoptosis-related cysteine peptidase (CASP3) NM_ Peptidylprolyl isomerase A (Ppia / Cyclophillin A) BC Interleukin 23, alpha subunit p19 (IL23A) NM_ V-myc myelocytomatosis viral oncogene homolog (avian) (MYC) NM_ Lymphotoxin alpha (TNF superfamily, member 1) (LTA) NM_ Interleukin 1, beta (IL1B) NM_ CD14 antigen (CD14) NM_ Protein tyrosine phosphatase, receptor type, C (CD45) NM_ Kappa light polypeptide gene enhancer in B-cells 1(p105) (NFKB1) NM_ Intercellular adhesion molecule 1 (CD54) NM_ Cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) NM_ Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) NM_ Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (PTGS2) (Cox-2) NM_ Scinderin (SCIN) (adseverin) NM_ Actin, beta (ACTB) NM_ Kanmycin Resistant 21 Caspase 9, apoptosis-related cysteine peptidase (CASP9) NM_ Interleukin 15 (IL15) NM_ Tumor protein p53 NM_ CD8 antigen, alpha polypeptide (p32) (CD8A) NM_ Nitric oxide synthase 2A (inducible, hepatocytes) (NOS2A) NM_

14 Human Multitox Plex Human Multitox Plex 1 Cytochrome 2C19 (Cyp2C19) M Cytochrome 1A2 (Cyp1A2) Z Cytochrome 2D6 (Cyp2D6) NM_ Aldehyde dehydrogenase (ALDH1A1) NM_ Heme Oxygenase (HO) X Apoptosis related cysteine protease (CASP3) NM_ Peptidylprolyl isomerase A (Ppia / Cyclophillin A) BC Cyclooxygenase-2 (Cox2) AY Cytochrome 2C9 (Cyp2C9) M Cytochrome3A4 (Cyp3A4) NM_ CyclinD1 BC Growth arrest DNA damage 153 (GADD153) NM_ Growth arrest DNA damage 45 (GADD45) NM_ Proliferating cell nuclear antigen M Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) NM_ NADPH cytochrome P-450 reductase AF Cyclin dependent kinase inhibitor 1A (p21) NM_ Cytochrome1A1 (Cyp1A1) NM_ Cytochrome2B1 (Cyp2B1) M Cytochrome2E1 (Cyp2E1) NM_ Actin, beta (ACTB) NM_ UDP-glucuronosyltransferase AF Cytochrome4A11 (Cyp4A11) NM_ Kanmycin Resistant 25 Tumor protein p53 (p53) AF NAD(P)H dehydrogenase quinone 1 (NQO1) NM_

15 Human Reference Plex Human Reference Plex 1 Ezrin X QRSHs glutaminyl-trna synthetase X Histone deacetylase HD1 U Transferrin Receptor BC Nuclear factor NF45 U MLN51 X Glycerol kinase NM_ Proteasome subunit Y D Ribosomal protein L37a (RPL37A) L S rrna M E2 Ubiquitin conjugating enzyme UbcH5B U Elongation factor EF-1-alpha NM_ Peptidylprolyl isomerase A (Ppia / Cyclophillin A) BC Lysosomal hyaluronidase AJ Transcription Factor IID X Actin, beta (ACTB) NM_ Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) NM_ ATP synthase X kDa Alu RNA binding protein (SRP14) NM_ Hypoxanthine ribosyl transferase M Beta 2 microglobulin NM_ Ca2-activated neutral protease large subunit M Kanamycin Resistant Kan(r) 24 Acidic Ribosomal Protein NM_ Beta-glucuronidase NM_

16 Human Breast Cancer Plex Human Breast Cancer Plex 1 CDC42 binding protein kinase alpha NM_ RAB6B, member RAS oncogene family NM_ BCL2 binding component 3 U Keratin 18 NM_ V-myb myeloblastosis viral oncogene homolog NM_ Egl nine homolog 1 NM_ Peptidylprolyl isomerase A (Ppia / Cyclophillin A) BC Ceruloplasmin (ferroxidase) NM_ WNT1 inducible signaling pathway protein 1 NM_ oxoacid CoA transferase 1 NM_ Aldehyde dehydrogenase 4 family, member A1 NM_ Collagen, type IV, alpha 2 X Transforming growth factor, beta 3 NM_ Estrogen receptor 1 NM_ Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) NM_ Protein regulator of cytokinesis 1 NM_ Actin, beta (ACTB) NM_ Replication factor C (activator 1) 4 NM_ Exostoses (multiple) 1 NM_ Kanamycin Resistant 21 Insulin-like growth factor binding protein 5 L Kinetochore associated 2 NM_ Guanine nucleot. binding protein (G protein), alpha z polypeptide NM_ Deoxycytidine kinase NM_ Adaptor-related protein complex 2, beta 1 subunit NM_

17 Human Multitox Plex Human Multitox Plex 1 Plasminogen activator, tissue (PLAT),transcript variant 1 NM_ V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (ERBB2), transcript variant 1 NM_ Pitrilysin metallopeptidase 1 (PITRM1) NM_ Mucin 1, transmembrane (MUC1), transcript variant 1 NM_ Cyclin E2 (CCNE2), transcript variant 3 NM_ Baculoviral IAP repeat-containing 5 (survivin) (BIRC5), transcript variant 1 NM_ Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)(egfr), transcript variant 1 NM_ V-myc myelocytomatosis viral oncogene homolog (avian) (MYC) NM_ Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (MMP9) NM_ Transferrin receptor (p90, CD71) (TFRC), NM_ Fibroblast growth factor 2 (basic) (FGF2), NM_ Vascular endothelial growth factor BC Cyclin D1 BC Cyclin-dependent kinase inhibitor 1A (p21, Cip1) (CDKN1A) NM_ Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) NM_ Peptidylprolyl isomerase A (Ppia / Cyclophillin A) BC Actin, beta (ACTB) NM_ SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal) (SOX9) NM_ Kanamycin Resistant 20 P53 protein AF

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