OIE Reference Laboratory Reports Activities
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1 OIE Reference Laboratory Reports Activities Activities in 2015 This report has been submitted : :13:09 Name of disease (or topic) for which you are a designated OIE Reference Laboratory: Rabies Address of laboratory: 1600 Clifton Road, NE, Mail Stop G33 Atlanta, GA UNITED STATES OF AMERICA Tel.: Fax: address: rpf5@cdc.gov Website: Name (including Title) of Head of Laboratory (Responsible Official): Vicki Olson, PhD, acting branch chief Name (including Title and Position) of OIE Reference Expert: Richard Franka, DVM, PhD, MPH, CPH Which of the following defines your laboratory? Check all that apply: Governmental OIE Reference Laboratory Reports Activities,
2 ToR 1: To use, promote and disseminate diagnostic methods validated according to OIE Standards 1. Did your laboratory perform diagnostic tests for the specified disease/topic for purposes such as disease diagnosis, screening of animals for export, surveillance, etc.? (t for quality control, proficiency testing or staff training) Diagnostic Test Indicated in OIE Manual (/) Total number of test performed last year Indirect diagnostic tests Nationally Internationally RFFIT Direct diagnostic tests Nationally Internationally DFA drit 10 0 IHC 15 0 Antigenic typing PCR and sequencing ToR 2: To develop reference material in accordance with OIE requirements, and implement and promote the application of OIE Standards. To store and distribute to national laboratories biological reference products and any other reagents used in the diagnosis and control of the designated pathogens or disease. 2. Did your laboratory produce or supply imported standard reference reagents officially recognised by the OIE? 3. Did your laboratory supply standard reference reagents (non OIE-approved) and/or other diagnostic reagents to OIE Member Countries? 2 OIE Reference Laboratory Reports Activities, 2015
3 Type of reagent available Related diagnostic test Produced/ provide Amount supplied nationally (ml, mg) Amount supplied internationally (ml, mg). of recipient OIE Member Countries Region of recipients Gama-irradiated positive controls DFA, DRIT brain 0 5ml 1 Africa America s Asia and Pacific Europe Middle East 4. Did your laboratory produce vaccines? 5. Did your laboratory supply vaccines to OIE Member Countries? ToR 3: To develop, standardise and validate, according to OIE Standards, new procedures for diagnosis and control of the designated pathogens or diseases 6. Did your laboratory develop new diagnostic methods validated according to OIE Standards for the designated pathogen or disease? 7. Did your laboratory develop new vaccines according to OIE Standards for the designated pathogen or disease? Name of the new test or diagnostic method or vaccine developed Real-time PCR for rabid detection of lyssaviruses in brain, skin, saliva and cornea. Description and References (Publication, website, etc.) Validation and standardization is currently in progress. ToR 4: To provide diagnostic testing facilities, and, where appropriate, scientific and technical advice on disease control measures to OIE Member Countries 8. Did your laboratory carry out diagnostic testing for other OIE Member Countries? OIE Reference Laboratory Reports Activities,
4 Name of OIE Member Country seeking assistance Date (month). samples received for provision of diagnostic support. samples received for provision of confirmatory diagnoses BRAZIL DOMINICAN (REP.) PERU CHINESE TAIPEI FRANCE HAITI TRINIDAD AND TOBAGO Did your laboratory provide expert advice in technical consultancies on the request of an OIE Member Country? Name of the OIE Member Country receiving a technical consultancy Purpose How the advice was provided HAITI Development of animal rabies surveillance system in country meetings, s, hands-on trainings ETHIOPIA Implementation of rabies control and prevention program, including enhancement of laboratory capacity and evaluation of surveillance systems. In country meetings, s, conf calls, VIETNAM Enhancement of laboratory diagnostic, implementation of rabies surveillance system, including wildlife disease surveillance. in country training, meetings, conf calls, s INDIA Development of the OIE twinning project s, conf calls, GEORGIA Enhancement of laboratory diagnostic capacity hands-on in country raining CONGO (DEM. REP. OF THE) enhancement of animal rabies surveillance in country hands-on training CHINA (PEOPLE'S REP. OF) rabies vaccine development conf calls, s ToR 5: To carry out and/or coordinate scientific and technical studies in collaboration with other laboratories, centres or organisations 10. Did your laboratory participate in international scientific studies in collaboration with OIE Member Countries other than the own? 4 OIE Reference Laboratory Reports Activities, 2015
5 Title of the study Duration Purpose of the study Partners (Institutions) KAP survey of dog owners attending mass dog vaccination campaign continuous To identify knowledge, attitude and practices of dog owners in Haiti MARNDR, Christian Veterinary Mission, Establishment of laboratory-based surveillance of wildlife diseases continous animal rabies surveillance in Vietnam MoAg, MoH ToR 6: To collect, process, analyse, publish and disseminate epizootiological data relevant to the designated pathogens or diseases 11. Did your Laboratory collect epizootiological data relevant to international disease control? 12. Did your laboratory disseminate epizootiological data that had been processed and analysed? 13. What method of dissemination of information is most often used by your laboratory? (Indicate in the appropriate box the number by category) a) Articles published in peer-reviewed journals: Wallace RM, Reses H, Franka R, Dilius P, Fenelon N, Orciari L, Etheart M, Destine A, Crowdis K, Blanton JD, Francisco C, Ludder F, Del Rio Vilas V, Haim J, Millien M. (2015). Establishment of a Canine Rabies Burden in Haiti through the Implementation of a vel Surveillance Program. PLoS Negl Trop Dis v 24;9(11):e Gilbert, A., Greenberg, L., Moran, D., Alvarez, D., Alvarado, M., Garcia, D.L., and Peruski, L Antibody Response of Cattle to Vaccination with Commercial Modified Live Rabies Vaccines in Guatemala. 3..Hampson, K., L. Coudeville, T. Lembo, M. Sambo, A. Kieffer, M. Attlan, J. Barrat, J. D. Blanton, D. J. Briggs, S. Cleaveland, P. Costa, C. M. Freuling, E. Hiby, L. Knopf, F. Leanes, F. X. Meslin, A. Metlin, M. E. Miranda, T. Muller, L. H. Nel, S. Recuenco, C. E. Rupprecht, C. Schumacher, L. Taylor, M. A. Vigilato, J. Zinsstag, J. Dushoff, and P. Global Alliance for Rabies Control Partners for Rabies. 2015b. Estimating the global burden of endemic canine rabies. PLoS Negl Trop Dis 9:e Lankau, E. W., S. W. Cox, S. C. Ferguson, J. D. Blanton, D. M. Tack, B. W. Petersen, and C. E. Rupprecht Community survey of rabies knowledge and exposure to bats in homes - Sumter County, South Carolina, USA. Zoonoses Public Health 62: McNeil, C. S., S. Nagy, C. Moonan, R. M. Wallace, N. M. Vora, J. L. Dyer, J. D. Blanton, T. Dorado, M. L. Heinrich, R. Sankey, S. Uhrig, A. Cary, W. Houghton, and P. Ettestad Community rabies knowledge and pet vaccination practices after a skunk rabies outbreak in Eddy County, New Mexico. J Am Vet Med Assoc 246: Millien, M. F., J. B. Pierre-Louis, R. Wallace, E. Caldas, M. Rwangabgoba, J. L. Poncelet, O. Cosivi, and V. J. del Rio Vilas Control of dog mediated human rabies in Haiti: no time to spare. PLoS Negl Trop Dis 9:e doi: /journal.pntd Moore, M. C., R. D. Davis, Q. Kang, C. I. Vahl, R. M. Wallace, C. A. Hanlon, and D. A. Mosier Comparison of OIE Reference Laboratory Reports Activities,
6 anamnestic responses to rabies vaccination in dogs and cats with current and out-of-date vaccination status. J Am Vet Med Assoc 246: Moran, D., P. Juliao, D. Alvarez, K. A. Lindblade, J. A. Ellison, A. T. Gilbert, B. Petersen, C. Rupprecht, and S. Recuenco Knowledge, attitudes and practices regarding rabies and exposure to bats in two rural communities in Guatemala. BMC Res tes 8:2. 9. Smith, T. G., M. Siirin, X. Wu, C. A. Hanlon, and V. Bronshtein Rabies vaccine preserved by vaporization is thermostable and immunogenic. Vaccine 33: Vora, N. M., J. R. Clippard, M. G. Stobierski, K. Signs, and J. D. Blanton. 2015a. Animal bite and rabies postexposure prophylaxis reporting--united States, J Public Health Manag Pract 21:E Wang, S., Sun, C., Shang, S., Zhang, X., Liu, Y., Wang, Y., Zhang, F., Wu, X., Hu, R Glycoprotein from street rabies virus bd06 induces early and robust immune responses when expressed from a non-replicative adenovirus recombinant. Arch Virol Sep;160(9): Sinclair JR, Wallace RM, Gruszynski K, Freeman MB, Campbell C, Semple S, Innes K, Slavinski S, Palumbo G, Bair-Brake H, Orciari L, Condori RE, Langer A, Carroll DS, Murphy J. (2015). Rabies in a Dog Imported from Egypt with a Falsified Rabies Vaccination Certificate - Virginia, MMWR Morb Mortal Wkly Rep Dec 18;64(49): Chang SS, Tsai HJ, Chang FY, Lee TS, Huang KC, Fang KY, Wallace RM, Inoue S, Fei CY.(2015). Government Response to the Discovery of a Rabies Virus Reservoir Species on a Previously Designated Rabies-Free Island, Taiwan, Zoonoses Public Health v 6. doi: /zph b) International conferences: 4 1. RITA WHO/OIE/FAO meeting, Geneva, 3. PARACORN 4. REDIPRA c) National conferences: 3 1. ASCLS Annual Meeting 2. EIS conference 3. USDA meeting d) Other: (Provide website address or link to appropriate information) 0 NA ToR 7: To provide scientific and technical training for personnel from OIE Member Countries To recommend the prescribed and alternative tests or vaccines as OIE Standards 14. Did your laboratory provide scientific and technical training to laboratory personnel from other OIE Member Countries? a) Technical visits: 7 b) Seminars: 3 c) Hands-on training courses: 3 d) Internships (>1 month): 0 6 OIE Reference Laboratory Reports Activities, 2015
7 Type of technical training provided (a, b, c or d) Country of origin of the expert(s) provided with training. participants from the corresponding country A Haiti, Vietnam, Ethiopia, DRC 28 B Haiti 100 C Haiti, Vietnam, republic of Georgia 59 ToR 8: To maintain a system of quality assurance, biosafety and biosecurity relevant for the pathogen and the disease concerned 15. Does your laboratory have a Quality Management System certified according to an International Standard? Quality management system adopted CLIA Certificate scan (PDF, JPG, PNG format) CDC rabies laboratory CLIA.pdf ISO pending 16. Is your laboratory accredited by an international accreditation body? Test for which your laboratory is accredited RFFIT, DFA, PCR Accreditation body EU Reference laboratory for Rabies 17. Does your laboratory maintain a biorisk management system for the pathogen and the disease concerned? (See Manual of Diagnostic Tests and Vaccines for Terrestrial Animals 2014, Chapter 1.1.3a) ToR 9: To organise and participate in scientific meetings on behalf of the OIE 18. Did your laboratory organise scientific meetings on behalf of the OIE? 19. Did your laboratory participate in scientific meetings on behalf of the OIE? OIE Reference Laboratory Reports Activities,
8 ToR 10: To establish and maintain a network with other OIE Reference Laboratories designated for the same pathogen or disease and organise regular inter-laboratory proficiency testing to ensure comparability of results 20. Did your laboratory exchange information with other OIE Reference Laboratories designated for the same pathogen or disease? 21. Was your laboratory involved in maintaining a network with OIE Reference Laboratories designated for the same pathogen or disease by organising or participating in proficiency tests? Purpose of the proficiency tests: 1 Role of your Reference Laboratory (organiser/ participant). participants Participating OIE Ref. Labs/ organising OIE Ref. Lab. EU Reference laboratory for Rabies, DFA, RFFIT, PCR participant 67 all 1 validation of a diagnostic protocol: specify the test; quality control of vaccines: specify the vaccine type, etc. 22. Did your laboratory collaborate with other OIE Reference Laboratories for the same disease on scientific research projects for the diagnosis or control of the pathogen of interest? Title of the project or contract Scope Name(s) of relevant OIE Reference Laboratories WHO/OIE/FAO Global framework for elimination of human rabies of canine origin by 2030 all ToR 11: To organise inter-laboratory proficiency testing with laboratories other than OIE Reference Laboratories for the same pathogens and diseases to ensure equivalence of results 23. Did your laboratory organise or participate in inter-laboratory proficiency tests with laboratories other than OIE Reference Laboratories for the same disease? 8 OIE Reference Laboratory Reports Activities, 2015
9 te: See Interlaboratory test comparisons in: Laboratory Proficiency Testing at: see point 1.3 Purpose for inter-laboratory test comparisons 1. participating laboratories Region(s) of participating OIE Member Countries DFA/DRIT, Wisconsin Laboratory 120 Africa Americas Asia and Pacific Europe Middle East ToR 12: To place expert consultants at the disposal of the OIE 24. Did your laboratory place expert consultants at the disposal of the OIE? 25. Additional comments regarding your report: OIE Reference Laboratory Reports Activities,
OIE Reference Laboratory Reports Activities
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