OIE Reference Laboratory Reports Activities

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1 OIE Reference Laboratory Reports Activities Activities in 2015 This report has been submitted : :55:39 Name of disease (or topic) for which you are a designated OIE Reference Laboratory: Rabies Address of laboratory: New Haw, Addlestone Surrey KT15 3NB Weybridge UNITED KINGDOM Tel.: Fax: address: tony.fooks@apha.gsi.gov.uk Website: Name (including Title) of Head of Laboratory (Responsible Official): Professor Anthony R. Fooks Name (including Title and Position) of OIE Reference Expert: Professor Anthony R. Fooks Which of the following defines your laboratory? Check all that apply: Governmental OIE Reference Laboratory Reports Activities,

2 ToR 1: To use, promote and disseminate diagnostic methods validated according to OIE Standards 1. Did your laboratory perform diagnostic tests for the specified disease/topic for purposes such as disease diagnosis, screening of animals for export, surveillance, etc.? (t for quality control, proficiency testing or staff training) Diagnostic Test Indicated in OIE Manual (/) Total number of test performed last year Indirect diagnostic tests Nationally Internationally Fluorescent antibody virus neutralisation test (FAVN) Direct diagnostic tests Nationally Internationally Fluorescent antibody test (FAT) Cell culture test (RTCIT) Real time Taqman PCR assay Reverse-transcriptase Polymerase Chain (RT- PCR) 3 0 ToR 2: To develop reference material in accordance with OIE requirements, and implement and promote the application of OIE Standards. To store and distribute to national laboratories biological reference products and any other reagents used in the diagnosis and control of the designated pathogens or disease. 2. Did your laboratory produce or supply imported standard reference reagents officially recognised by the OIE? 3. Did your laboratory supply standard reference reagents (non OIE-approved) and/or other diagnostic reagents to OIE Member Countries? 2 OIE Reference Laboratory Reports Activities, 2015

3 Type of reagent available Related diagnostic test Produced/ provide Amount supplied nationally (ml, mg) Amount supplied internationally (ml, mg). of recipient OIE Member Countries Region of recipients Ikoma lyssavirus (IKOV) RTCIT/FAT/RT-PCR Provided 1ml 2 Africa America s Asia and Pacific Europe Middle East Challenge virus standard (CVS) RTCIT/FAT/RT-PCR Provided 1ml 1 Africa America s Asia and Pacific Europe Middle East Rabies virus (RABV) RTCIT/FAT/RT-PCR Provided 1ml 2 Africa America s Asia and Pacific Europe Middle East Rabies virus RNA (RABV RNA) RT-PCR Provided 60µl x 8 1 Africa America s Asia and Pacific Europe Middle East 4. Did your laboratory produce vaccines? 5. Did your laboratory supply vaccines to OIE Member Countries? ToR 3: To develop, standardise and validate, according to OIE Standards, new OIE Reference Laboratory Reports Activities,

4 procedures for diagnosis and control of the designated pathogens or diseases 6. Did your laboratory develop new diagnostic methods validated according to OIE Standards for the designated pathogen or disease? 7. Did your laboratory develop new vaccines according to OIE Standards for the designated pathogen or disease? ToR 4: To provide diagnostic testing facilities, and, where appropriate, scientific and technical advice on disease control measures to OIE Member Countries 8. Did your laboratory carry out diagnostic testing for other OIE Member Countries? 4 OIE Reference Laboratory Reports Activities, 2015

5 Name of OIE Member Country seeking assistance Date (month). samples received for provision of diagnostic support. samples received for provision of confirmatory diagnoses TANZANIA January ETHIOPIA February 41 6 ETHIOPIA March 15 3 ETHIOPIA April 54 1 ETHIOPIA May 18 6 INDIA May 4 4 COTE D'IVOIRE May SYRIA May 2 2 KUWAIT June 1 1 GEORGIA June 8 8 TANZANIA July GHANA July 16 0 GEORGIA July ETHIOPIA July AZERBAIJAN August TURKEY August ETHIOPIA September 6 1 SRI LANKA September 4 4 SPAIN October 1 1 NORWAY October 1 1 ETHIOPIA October 14 2 SINGAPORE vember 2 2 SRI LANKA vember 2 2 GEORGIA December Did your laboratory provide expert advice in technical consultancies on the request of an OIE Member Country? OIE Reference Laboratory Reports Activities,

6 Name of the OIE Member Country receiving a technical consultancy Purpose How the advice was provided AZERBAIJAN Training Technical workshops in-country. GEORGIA Training Technical hosting in the UK to provide training advice. ToR 5: To carry out and/or coordinate scientific and technical studies in collaboration with other laboratories, centres or organisations 10. Did your laboratory participate in international scientific studies in collaboration with OIE Member Countries other than the own? Title of the study Duration Purpose of the study Partners (Institutions) European Virus Archive Global 4 years EU-funded project for the characterisation of viruses. Advanced studies towards knowledge on lyssavirus encephalitis and pathogenesis: Improving options for survivial 3 years Developments of antivirals against rabies. ToR 6: To collect, process, analyse, publish and disseminate epizootiological data relevant to the designated pathogens or diseases 11. Did your Laboratory collect epizootiological data relevant to international disease control? 12. Did your laboratory disseminate epizootiological data that had been processed and analysed? 13. What method of dissemination of information is most often used by your laboratory? (Indicate in the appropriate box the number by category) a) Articles published in peer-reviewed journals: 8 1. Marston, D.A., Vázquez-Morón, S., Ellis, R.J., Wise, E.L., McElhinney, L.M., de Lamballerie, X., Fooks, A.R. and J.E. Echevarría (2015). Complete Genomic Sequence of European Bat Lyssavirus 1 isolated from Eptesicus isabellinus in Spain. Genome Announcements 12;3(1). pii: e doi: /genomeA Fooks, A.R. and N. Johnson (2015). Jet set pets: Examining the Zoonosis Risk in Animal Import and Travel. 6 OIE Reference Laboratory Reports Activities, 2015

7 Veterinary Medicine: Research and Reports 6; Rabies - Anthony Fooks - united kingdom 3. Horton, D.L., McElhinney, L.M., Freuling, C.M., Marston, D.A., Banyard, A.C., Goharrriz, H., Wise, E., Breed, A.C., Saturday, G., Kolodziejek, J., Zilahi, E., Al-Kobaisi. M.F., wotny, N., Mueller T. and A.R. Fooks (2015). Complex epidemiology of a zoonotic disease in a culturally diverse region: phylogeography of rabies virus in the Middle East. PLoS Neglected Tropical Diseases 9(3); e Marston, D.A., Wise, E.L., Ellis, R.J., McElhinney, L.M., Banyard, A.C., Johnson, N., Deressa, A., Regassa, F., de Lamballerie, X., Fooks, A.R. and C. Sillero-Zubiri (2015). Complete genomic sequence of rabies virus from an Ethiopian wolf. Genome Announcements 3(2); pii: e Gordon, C.H., Banyard, A.C., Hussein, A., Laurenson, M.K., Malcolm, J.R., Marino, J., Regassa, F., Stewart, A-M.E., Fooks, A.R. and C. Sillero-Zubiri (2015). Canine Distemper in Endangered Ethiopian Wolves. Emerging Infectious Diseases 21(5); Morters, M.K., McNabb, S., Horton, D.L., Fooks, A.R., Schoeman, J.P., Whay, HR., Wood, J.L., Cleaveland, S. (2015). Effective vaccination against rabies in puppies in rabies endemic regions. The Veterinary Record 177(6); Sabeta, C., Phahladira, B., Marston, D., Wise, E., Ellis, R and A.R. Fooks (2015). Complete genomic sequences of six southern African rabies viruses Genome Announcements 3(5). 8. Brunker, K., Marston, D., Horton, D., Cleaveland, S., Fooks, A.R., Kazwala, R., Ngeleja, C., Lembo, T., Sambo, M., Mtema, Z., Sikana, L., Wilkie, G., Biek, R., and K. Hampson (2015). Elucidating the phylodynamics of endemic rabies virus in eastern Africa using whole genome sequencing. Virus Evolution 1(1). b) International conferences: 9 1. International One Health Congress, Rabies Satellite Symposium, Amsterdam, The Netherlands [Mar 2015] 2. OIE Regional Rabies Scientific Conference, Wuhan, China [Apr 2015] 3. 8th Partners in Rabies Prevention / Global Alliance for Rabies Control meeting, Zurich, Switzerland [May 2015] 4. 28th International Conference on Antiviral Research, Rome, Italy [May 2015] 5. OIE Global Conference on Biological Threat Reduction, Paris, France [July 2015] 6. RAPIDD Small Mammals Reservoirs Working Group Meeting, Ft. Collins, Colorado, USA [July 2015] 7. 9th Vaccine and ISV Congress, Seoul, Republic of Korea [Oct 2015] 8. Regional Seminar for OIE National Focus Point for Veterinary Laboratories [Oct 2015] 9. Global Conference of dog-mediated human rabies The Time is w, Geneva, Switzerland [Dec 2015] c) National conferences: 3 1. World Health Organization meeting of the 3rd WHO Report on Neglected Tropical Diseases, London, UK [Feb 2015] 2. Donor Transmitted Encephalitis Cases, London, UK [Mar 2015] 3. Society for General Microbiology, Birmingham, UK [Apr 2015] d) Other: (Provide website address or link to appropriate information) 1 1. Muller, T., Freuling, C.M., Rupprecht, C.E., Both, L. Fooks, A.R., Lembo, T., Knopf, L., Briggs, D.J amd L.H. Taylor (2015). Elimination of Rabies - A Missed Opportunity (Chapter 21). In: Zoonoses - Infections Affecting Humans and Animals (Ed: A. Sing), Published by SpringerScience+Business Media, Dordrecht, Germany, pp ToR 7: To provide scientific and technical training for personnel from OIE Member Countries To recommend the prescribed and alternative tests or vaccines as OIE Standards 14. Did your laboratory provide scientific and technical training to laboratory personnel from other OIE Member Countries? OIE Reference Laboratory Reports Activities,

8 a) Technical visits: 1 b) Seminars: 1 c) Hands-on training courses: 1 d) Internships (>1 month): Type of technical training provided (a, b, c or d) Country of origin of the expert(s) provided with training. participants from the corresponding country (b) Azerbaijan 11 (c) Azerbaijan 13 (a) Georgia 2 ToR 8: To maintain a system of quality assurance, biosafety and biosecurity relevant for the pathogen and the disease concerned 15. Does your laboratory have a Quality Management System certified according to an International Standard? Quality management system adopted Certificate scan (PDF, JPG, PNG format) The laboratory facilities are UKAS accredited to BS EN ISO 17025:2005 (Lab s and 1769) for an extensive range of tests supported by proficiency testing accredited to ISO/IEC Guide (Lab. 0004). Copy of UKAS certificate.pdf 16. Is your laboratory accredited by an international accreditation body? Test for which your laboratory is accredited Accreditation body Fluorescent antibody virus neutralisation test (FAVN) UKAS (17025) Fluorescent antibody test (FAT) UKAS (17025) Taqman Real-Time RT-PCR UKAS (17025) RT-PCR UKAS (17025) Rabies tissue culture isolation test (RTCIT) UKAS (17025) 17. Does your laboratory maintain a biorisk management system for the pathogen and the disease concerned? (See Manual of Diagnostic Tests and Vaccines for Terrestrial Animals 2014, Chapter 1.1.3a) 8 OIE Reference Laboratory Reports Activities, 2015

9 ToR 9: To organise and participate in scientific meetings on behalf of the OIE 18. Did your laboratory organise scientific meetings on behalf of the OIE? 19. Did your laboratory participate in scientific meetings on behalf of the OIE? Title of event Date (mm/yy) Location Role (speaker, presenting poster, short communications) Title of the work presented EU representative for the Biologicals Standards Commission at the Working Party of Chief Veterinary Officers 02/15 Brussels, Belgium Speaker mination for the OIE Biological Standards Commission OIE Regional Rabies Scientific Conference 04/15 Wuhan, China Speaker Recent advances in rabies diagnosis International Ring Trial on Molecular Diagnostic Methods for African horse sickness 06/15 Pirbright, UK Dossier assessor t applicable Ad hoc Group on Vaccine Banks 06/15 Paris, France Invited expert t applicable Global Conference on Biological Threat Reduction 07/15 Paris, France Speaker Response to an alleged bioterror attack: oie s involvement (Expert's perspective) OIE Biological Standards Commission 09/15 Paris, France Member of BSC t applicable Regional Seminar for OIE National Focus Point for Veterinary Laboratories 10/2015 Cluj Napoca, Romania, Speaker (1) Structure of the OIE Manual of Diagnostic Tests and Vaccines for Terrestrial Animals (2) OIE Reference Centres: role, rights and commitments ToR 10: To establish and maintain a network with other OIE Reference Laboratories designated for the same pathogen or disease and organise regular inter-laboratory proficiency testing to ensure comparability of results 20. Did your laboratory exchange information with other OIE Reference Laboratories designated for the same OIE Reference Laboratory Reports Activities,

10 pathogen or disease? 21. Was your laboratory involved in maintaining a network with OIE Reference Laboratories designated for the same pathogen or disease by organising or participating in proficiency tests? Purpose of the proficiency tests: 1 Role of your Reference Laboratory (organiser/ participant). participants Participating OIE Ref. Labs/ organising OIE Ref. Lab. National rabies serology proficiency scheme (FAVN) Participant 2 UK ANSES international rabies serology proficiency scheme Participant circa. 50+ UK, France (organiser), Germany,Canada, South Africa. ANSES international rabies diagnostic proficiency scheme (FAT, RTCIT and PCR) Participant circa. 50+ UK, France (organiser), Germany, Canada, South Africa. 1 validation of a diagnostic protocol: specify the test; quality control of vaccines: specify the vaccine type, etc. 22. Did your laboratory collaborate with other OIE Reference Laboratories for the same disease on scientific research projects for the diagnosis or control of the pathogen of interest? Title of the project or contract Scope Name(s) of relevant OIE Reference Laboratories Complex epidemiology of a zoonotic disease in a culturally diverse region: phylogeography of rabies virus in the Middle East. Undertook genetic characterisation of rabies virus isolates circulating in the Middle East. OIE RL for rabies in Germany (FLI). Complete genomic sequences of six southern African rabies viruses Undertook genetic characterisation of rabies virus isolates circulating in southern Africa. OIE RL for rabies in Republic of South Africa (OVI). ToR 11: To organise inter-laboratory proficiency testing with laboratories other than OIE Reference Laboratories for the same pathogens and diseases to ensure equivalence of results 23. Did your laboratory organise or participate in inter-laboratory proficiency tests with laboratories other than OIE Reference Laboratories for the same disease? 10 OIE Reference Laboratory Reports Activities, 2015

11 te: See Interlaboratory test comparisons in: Laboratory Proficiency Testing at: see point 1.3 Purpose for inter-laboratory test comparisons 1. participating laboratories Region(s) of participating OIE Member Countries National rabies serology proficiency scheme 2 Africa Americas Asia and Pacific Europe Middle East ToR 12: To place expert consultants at the disposal of the OIE 24. Did your laboratory place expert consultants at the disposal of the OIE? Kind of consultancy Location Subject (facultative) Expert representing the OIE Biological Standards Commission Paris, France Vaccine banks Member of the OIE Biological Standards Commission Pirbright, UK International Ring Trial on Molecular Diagnostic Methods for African horse sickness. Member of the OIE Biological Standards Commission Paris, France Review of the Manual of Diagnostic Tests and Vaccines for Terrestrial Animals. 25. Additional comments regarding your report: OIE Reference Laboratory Reports Activities,

OIE Reference Laboratory Reports Activities

OIE Reference Laboratory Reports Activities Activities in 2016 This report has been submitted : 2017-01-31 14:46:00 Name of disease (or topic) for which you are a designated OIE Reference Laboratory: Newcastle